|"Old Flames, New Sparks"|
|Season 4, Episode 16|
|Air date||February 27, 2019|
|Written by||Teleplay by: Safura Fadavi
Story by: Safura Fadavi & Meridith Friedman
|Directed by||Elodie Keene|
"We Hold These Truths"
"The Space Between Us"
Natalie and Will grow further apart. Dr. Charles struggles to come to terms with his feelings toward his ex-wife. The personal issues between Dr. Rhodes and Dr. Bekker continue to cause problems at the hospital.
- Brian Tee as Dr. Ethan Choi
- Colin Donnell as Dr. Connor Rhodes
- Marlyne Barrett as Maggie Lockwood
- Nick Gehlfuss as Dr. Will Halstead
- Norma Kuhling as Dr. Ava Bekker
- Oliver Platt as Dr. Daniel Charles
- S. Epatha Merkerson as Sharon Goodwin
- Torrey DeVitto as Dr. Natalie Manning
- Yaya DaCosta as Nurse April Sexton