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Infection, Part II is the fourth episode of Season 5 of Chicago Med. It is the second part of a three-part One Chicago Crossover event with Chicago Fire and Chicago P.D. The event starts with Infection, Part I, continues with this episode and concludes with Infection, Part III.


The entire population of an apartment complex is forced into quarantine when multiple cases of a flesh-eating bacteria are discovered. The Chicago P.D. Intelligence Unit chases a lead that could point to a case of bioterrorism, while multiple patients succumb to the disease. Dr. Halstead works closely with a representative from the CDC and doctors from the involved university lab, putting him dangerously close to the suspect. Meanwhile, Sharon Goodwin deals with the press.


Main Cast[]

Crossover Cast[]

Recurring Cast[]

Guest Cast[]


The episode highlights multiple aspects of a mass panic induced by an infectious disease outbreak:

  • The way panic spreads throughout a population as news spreads
  • Sensationalist coverage by news media
  • Conspiracy theories
  • People with immigrant backgrounds being blamed for the spread of a disease
  • Tensions between public health and financial/PR considerations

Medical Cases[]

Many patients are surgically treated in an attempt to remove infected tissue, with multiple patients succumbing. One patient is saved by amputating an infected arm.

Notes and Trivia[]

  • The samples of the flesh-eating bacteria are said to require the highest level (level 4) of biomedical security, but the characters are seen handling them without any protective gear. Similarly, Dr. Marcel is seen wiping his face with a hand covered in blood from a patient who has just died of the bacteria.