|"Be My Better Half"|
|Season 4, Episode 01|
|Air date||September 26, 2018|
|Written by||Diane Frolov & Andrew Schneider|
|Directed by||Michael Waxman|
"The Tipping Point"
"When To Let Go"
Goodwin finds herself quickly clashing with the new hospital COO Gwen Garrett while April questions whether or not Ethan's sister, Emily, is using again. Dr. Charles deals with his past actions.
- Brian Tee as Dr. Ethan Choi
- Colin Donnell as Dr. Connor Rhodes
- Marlyne Barrett as Maggie Lockwood
- Nick Gehlfuss as Dr. Will Halstead
- Norma Kuhling as Dr. Ava Bekker
- Oliver Platt as Dr. Daniel Charles
- Rachel DiPillo as Dr. Sarah Reese
- S. Epatha Merkerson S. Epatha Merkerson as Sharon Goodwin
- Torrey DeVitto as Dr. Natalie Manning
- Yaya DaCosta as Nurse April Sexton